Metalloenzyme Browser and Statistics
Detailed browser for curated metalloenzyme information and statistics
Structure and Metal Active Site Superimposition
Metalloenzyme structure alignments by structure and metal active sites
Metal Site Browser
Browser for metalloenzyme metal binding sites
Metalloenzyme Ligand Search and Statistics
Detailed browser for ligand information and statistics
Drugs and Drug Candidates Targeting Metalloenzymes
Broswer for drugs and drug candidates targeting metalloenzymes
Metal-Binding Pharmacophore Search
Search for metal-binding pharmacophore binding modes and ligands
Metalloenzyme Profiling
Profiling metalloenzymes by ligand similarity
Welcome to
MeDBA
MeDBA aims to provide an integrated, distinctive, practicable, user-friendly platform for metalloenzyme-focused data bank and analysis. It integrates information regarding metalloenzymes, ligands, metalloenzyme-ligand associations with metalloenzyme-specific analysis tools, which will help understand and investigate metalloenzyme-involved contents, and will promote and bridge metalloenzyme-related areas (e.g., biological chemistry, structural and chemical biology, synthetic biology, bioinorganic chemistry, medicinal chemistry, computational chemistry and drug discovery). MeDBA is developed and maintained by Prof. Guo-Bo Li's group.
Latest release
June 30, 2026
- Updated metalloenzyme entries
- Enriched metalloenzyme annotations
- Introduced new modules
MeDBA Statistics
| No. of metalloenzymes | 97720 |
| No. of human metalloenzymes | 1756 |
| No. of metalloenzyme families (InterPro) | 12238 |
| No. of metalloenzyme-related diseases (ICD-11) | 928 |
| No. of metalloenzyme-related diseases (MeSH) | 1242 |
| No. of metalloenzyme structures | 84713 |
| No. of metalloenzyme structure models | 26682 |
| No. of metal site classes | 2348 |
| No. of metalloenzyme-ligand complexes | 11317 |
| No. of metalloenzyme-protein complexes | 7971 |
| No. of metalloenzyme-DNA/RNA complexes | 3886 |
| No. of metal binding pharmacophores | 1629 |
| No. of bioactive ligands | 595216 |
| No. of metalloenzyme substrates/products | 3457 |
| No. of PROTACs targeting metalloenzymes | 3333 |
| No. of drugs targeting metalloenzymes | 511 |
| No. of drug candidates targeting metalloenzymes | 7164 |
Category M-I
Metalloenzymes: 87680 Structures: 57819 Complexes: 7525 Bioactive ligands: 252256 Drugs: 338 Drug candidates: 4578
Category M-II
Metalloenzymes: 9148 Structures: 20712 Bioactive ligands: 275799 Drugs: 129 Drug candidates: 1850